News & Publications

Publications

	Hassanein, AASLD poster on PAGN 2011
	Hassanein, AASLD poster on HE 2011
	"Reduction in Hyperammonaemia with OCR-002 (L-Ornithine Phenylacetate) in Bile-Duct-Ligated (BDL) Cirrhotic Rats Restores Brain Enos Activity by Modulating the DDAH-ADMA Pathway" Balasubramaniyan AASLD Poster 2010
	"The Mechanism Behind Synergistic Action of L-Ornithine and Phenylacetate to Reduce Ammonia in Bile-Duct Ligated Rats" Jover-Cobos AASLD Poster 2010
	"Treatment of Hyperammonaemia with OCR-002 (L-Ornithine Phenylacetate) Reduces Portal Pressure by Modulating Hepatic NFkB and Hepatic eNOS Activity in Cirrhotic Rats" Mookerjee AASLD Poster 2010
	"Ornithine Phenylacetate (OP) Prevents Neurophysiological Abnormalities in an Experimental Model of Hepatic Encephalopathy" Oria AASLD Poster/Abstract 2010
	Reduction in Hyperammonemia with L-Ornithine Phenylacetate (OCR-002) in Bile-Duct-Ligated (BDL) Cirrhotic Rats Restores Brain eNOS Activity by Modulating the DDAH - ADMA Pathway" Vairappan Abstract AASLD 2009
	"Reduction in Ammonia with L-Ornithine, Phenylacetate (OP) but not Anti-TNF Prevents LPS Induced Brain Edema In Bile-Duct Ligated Cirrhotic Rats" Wright EASL Abstract 2009
	"Targeting Ammonia & Inflammation With L-Ornithine, Phenylacetate (OP) and Infliximab for the Treatment of Advanced Hepatic Encephalopathy" Wright EASL Poster 2009
	"L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure", Ytrebø, Lars Marius, Hepatology, Vol. 50, No. 1, 2009
	"L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats", Nathan, Davies, Hepatology, Vol. 50, No. 1, 2009
	“L-Ornithine phenylacetate (OP): A Novel Treatment for Hyperammonemia and Hepatic Encephalopathy” Jalan, Medical Hypotheses 1 January 2007 (volume 69 issue 5 Pages 1064-1069)
	"L-Ornathine Phenylacetate Reduces Arterial Ammonia, Improves Brain Osmolytes and Reduces Brain Water in a Bile-Duct-Ligated Rat Model of Cirrhosis" Wright AASLD Abstract 2007
	"L-Ornithine Phenylacetate Attenuates Increase in Arterial Ammonia and Intracranial Pressure in a Devascularised Pig Model of Acute Liver Failure: a Novel Ammonia-Lowering Strategy For Hepatic Encephalopathy" Ytrebø AASLD Abstract 2007

	"AST-120 (spherical carbon adsorbent) Improves Pain and Bloating in a Randomized, Double-Blind, Placebo-Controlled Trial in Patients with Non-Constipating Irritable Bowel Syndrome (IBS)", Tack, J, EASL, 2010
	"Mild Hepatic Encephalopathy (HE) Assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is Highly Prevalent in Ambulatory Patients with Cirrhosis", Randolph, C, DDW 2010
	'"The Efficacy and Tolerability of AST-120 (Spherical Carbon Adsorbent) in Active Pouchitis", Shen, Bo, AJG, 2009
	"A Pilot Study on the Efficacy and Tolerability of AST-120 in the Treatment of Active Pouchitis", Shen, Bo, ACG, 2007 (Poster)
	"The Efficacy and Tolerability of AST-120 (Spherical Carbon Adsorbent) in Active Pouchitis", Shen, Bo, UEGW, 2008 (Poster)
	"Absence of Interactions Between AST-120 (Spherical Carbon Adsorbent), a Novel Oral Adsorbent, and Concomitant Medications: Azathioprine and CiproXR®", Willmer, Jonathan, UEGW (Poster)
	"Absence of Interactions Between AST-120 (Spherical Carbon Adsorbent), a Novel Oral Adsorbent, and Concomitant Medications: Azathioprine and CiproXR®", Willmer, Jonathan, UEGW (Abstract)
	"Prevention of GI Absorption of Bacterial Toxins: and In Vitro Evaluation of the Potential for Prophylactic Use of a Novel Oral Adsorbent (AST-120)", Anderson, Keith, DDW, 2008 (Abstract)
	"AST-120: A Novel, Engineered Carbon Microsphere Product fir Use in Chronic Inflammatory Bowel Disease and Liver Dysfunction", Anderson, Keith, DDW, 2008 (Abstract)
	"AST-120 (Spherical Carbon Adsorbent): A Novel, Engineered Carbon Microsphere Product for Use in Chronic Inflammatory Bowel Disease and Liver Function", Anderson, Keith, DDW, 2008 (Poster)
	"Prevention of GI Absorption of Bacterial Toxins: an In Vitro Evaluation on the Potential for Prophylactic Use of a Novel Oral Adsorbent (AST-120, Spherical Carbon Adsorbent)", Anderson, Keith, DDW, 2008 (Poster)
	"A Novel Oral Adsorbent, AST-120, Specifically and Irreversibly Binds Pro-Inflammatory Mediators of the Gut In Vitro and In Vivo", Anderson, Keith, UEGW, 2008 (Abstract)